The move comes in the wake of antisemitic statements and other offensive comments he made on multiple media platforms in the past month.
"Balenciaga has no longer any relationship nor any plans for future projects related to this artist," Kering — the parent company of the fashion house —informed Women's Wear Daily in a statement.
The announcement came in response to a query by the magazine, on Thursday, following the publication of the company's third-quarter results.
Balenciaga did not elaborate on the reasons for severing the relationship with Brown. It is safe to assume that the media firestorm enveloping his recent actions played a part.
The musician and fashion mogul worked closely with Balenciaga and its mononymous artistic director Demna for the past two years.
Balenciaga and Demna, who previously told Vogue in an interview that West is one of a few people who understand his work, seemingly have had enough of the mercurial artist.
It is unclear what the decision means for the businesses' relationship with West's ex-wife. Kim Kardashian has appeared in advertising campaigns for the brand after being introduced to it by West.